Coming Soon

A Personal Fertility Sensor Coming Soon

For women trying to conceive, Priya is an intravaginal ring being developed to help your patients effortlessly manage their fertility.   Priya works by wirelessly capturing continuous core body temperature to detect temperature patterns that occur PRIOR to ovulation.  Currently undergoing testing in clinical trials, the ring transmits temperature data directly to the Priya App on the patient's smartphone in real-time. 


What is Priya:

Priya - For the next generation of patients seeking precise personal monitoring

Priya is an intravaginal ring with the same dimensions and flexibility as Estring®. We use the same medical-grade silicone form-factor and have inserted a wireless continuous temperature sensor. Priya is intended to be an over-the-counter product that a woman can insert while in the comfort of her home. We have developed the technology for the data to be automatically transferred to the iOS Priya App and are testing the app to send an alert to the phone when Priya detects a dip in temperature. Temperature is continuously monitored and all the data are transferred to the Priya app on her iPhone. An algorithm is being tested to detect the DIP in temperature prior to ovulation.


There are no monitors, attachable extra sensors, urine strips, or replacement parts. All that is required is to pair the Priya Ring with the Priya App on the smartphone and then insert the ring.  Your patients can then go about their normal daily activities.  The Priya Ring is being designed vaginal use only. 

Unlike oral temperatures which measure Basel Body Temperature (BBT), Priya is an internal, continuous, core temperature sensor. Core temperature monitoring has been shown to be a more precise method for identifying ovulation compared with a once-daily oral thermometers or skin measurements (1,2,3). 


The Science Behind Priya


It is well know that a pre-ovulatory decline in core temperature takes place 24-48 hours prior to ovulation (2,3). When measured accurately, this decline provides an important tool for predicting ovulation (see figure below). Having intercourse during these pre-ovulatory days significantly increases the probability of conception (6).

Women’s bodies tightly control body temperature and exhibit a striking diurnal temperature pattern. This temperature pattern has been well studied and has been established as a highly reliable marker for circadian rhythm (8). Continuous core temperature monitoring can be used to precisely predict impending ovulation by identifying a dip in body temperature (circamensal nadir) as detected with multiple continuous temperature readings in the 48 hour period prior to ovulation. Based on continuous core temperature monitoring during clinical trials, the algorithms developed for Priya have been shown to achieve a 99% sensitivity for detection of ovulation, with a 99% percent accuracy.

In the published study conducted by Mary Coyne et al, "Circadian rhythm changes in core temperature over the menstrual cycle: method for noninvasive monitoring", core temperatures were measured every minute over the course of an entire menstrual cycle. The results of this study showed a beautiful circadian rhythm could more-reliably identify the temperature changes that precede ovulation. Even more impressive was that circadian rhythm could better-detect the important DIP in temperature that precedes the surge of luteinizing hormone by one or two days (2).

Therefore, oscillating temperature patterns can be measured accurately and precisely using a vaginal rings that are similar to those that women have been wearing for several years.  



  1. Engels H, Yarandi H, and Davis J. Validation of the ingestible Vital Sense temperature capsule.  Journal of Exercise Physiology. 2009; 12: 1
  2. Coyne et al. Circadian rhythm changes in core temperature over the menstrual cycle: method for noninvasive monitoring. Am J Physiol Regulatory Integrative Com Physiol 2000, 279:1316-132
  3. Cagnacci, A., Volpe, A., Paoletti, A.M., and Melis, G.B. Regulation of the 24-h rhythm of body temperature in menstrual cycles with spontaneous and gonadotropin-induced ovulation. Fertil Steril. 1997; 68: 421–425
  4. Johnson SR, Shaw R. Success of detection of LH surge by home ovulation tests. Fertil Steril. 2009; 2(3):S101. 
  5. Pray S and Pray G. Detecting Pregnancy and Ovulation with Home Test Kits. U.S. Pharmacist. Sep 2012
  6. Wilcox A, Weinberg C, and Baird D. Timing of sexual intercourse in relation to ovulation. 1995 NEJM 333(23):1517-1521
  7. Consumer Reports. Home Test Kits 5 Questions to Ask Before you Buy. June 8, 2009.
  8. Brown et al. A statistical model of the human core-temperature circadian rhythm. Am J Physiol Endocrinol Metab. 2000; 279: E669–E683.


    Who is Behind Priya?


    Alene Campbell, CEO. Alene has led several successful biotech and health care firms during her career, introducing groundbreaking and lifesaving technologies to market.  She has held leadership marketing, finance, sales and business development positions including VP of Corporate Development at Myogen (now Gilead), General Manager of RPI/SiRNA (now Merck), VP of Marketing and Sales, CFO and Executive VP of ChemTrak, (a consumer products company). Ms. Campbell holds an MBA from the University of California, Berkeley.

    Don Kirkpatrick, Chairman of the Board, Prima-Temp Inc. Don is the founder and Chairman of Cadre Technologies, the largest software provider to the third-party logistics in warehouse management and distribution technology. Don is an engineering graduate of Princeton University and Director of Denver School of Science and Technology.

    Rich Pollack, CTO and Co-Founder. Rich’s engineering team developed the temperature/pressure sensor in tires for Goodyear that later evolved into Phase IV Engineering in Boulder, CO. His engineering career spans 25 years experience including wireless temperature sensors for a variety of applications and is named in over 15 patents. He founded Phase IV and three other companies.

    Wade W. Webster, MD, CMO and Co-Founder. Dr. Webster is a practicing Emergency Physician at Evergreen Hospital Medical Center, Kirkland, Washington for 21 years. He received his Medical Degree from Albany Medical College in Albany, New York. Wade is currently the Chief Science Officer for DVM Systems, LLC, a system for early disease detection and reproduction that uses temperature monitoring in dairy cattle and ruminants.